Document Details

Document Type : Article In Journal 
Document Title :
The Role of Janus Kinase 2 (JAK2) in the Pathologenesis of Myeloproliferative Disorders
دور التايروسين كاينيز في تطور سرطان الدم المزمن
 
Document Language : English 
Abstract : The myeloproliferative disorders, polycythemia vera, essential thombocythemia, and primary myelofibrosis are clonal disorders of multipotent hematopoietic progenitors. The genetic cause of these diseases was not known until 2005, when several independent groups demonstrated that most patients with PV, ET and PMF acquired a single point mutation in the cytoplasmic tyrosine kinase, such as JAK2 (JAK2 V617F). These discoveries have changed the landscape for diagnosis and classification of PV, ET and PMF, and have shown the ability of genomic technologies to identify new molecular targets in human malignancies with pathogenetic, diagnostic and therapeutic significance. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 16 
Issue Number : 1 
Publishing Year : 1430 AH
2009 AD 
Article Type : Article 
Added Date : Sunday, January 17, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ممدوح عبدالله قارىGari, Mamdooh A.ResearcherDoctoratem_gari@hotmail.com

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