Document Details

Document Type : Article In Journal 
Document Title :
A Study of the Effect of Maternal Obesity on the Structure and Function of Pancreatic Islets in Newborn Rats
دراسة عن تأثير بدانة الأم على تركيب ووظيفة جزر البنكرياس في الفئران حديثة الولادة
 
Subject : Original Articles 
Document Language : English 
Abstract : Obesity is a global problem with high risks of cardiovascular diseases, stroke, and Type 2 diabetes. The current study aimed to clarify effects of maternal obesity on functional and structural integrity of pancreatic islets in newborn rats. Pancreatic specimens were obtained from 1-day-old newborn rats of obese and non-obese mothers. After processing, sections were stained with anti-insulin antibodies. A morphometry was performed on pancreatic islets. Blood glucose and insulin levels were measured in newborns of obese and non-obese mothers. The immunohistological structure of newborn pancreatic islets of obese mothers was normal and didn't differ from that of controls. Volume density, percentage of B cells per total islet cells and diameter of newborn pancreatic islets of obese mothers didn't vary significantly from that of controls. Blood glucose level of newborns of obese mothers was not significantly different from that of controls. The serum insulin of newborns of obese mothers was significantly higher than that of the controls. Maternal obesity didn't affect volume density of B cells, percentage of B cells per total islet cells, diameter of pancreatic islets and blood glucose level of rat newborns. However, obesity during pregnancy resulted in an increase of serum insulin of rat newborns. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 15 
Issue Number : 2 
Publishing Year : 1429 AH
2008 AD 
Number Of Pages : 11 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سمر محمد عمر السقافSamar M. Al-SaggafResearcher  

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