Document Details

Document Type : Article In Journal 
Document Title :
Simultaneous Determination of Candesartan Cilexetil Cilexetil and Hydrochlorothiazide by by High-Performance Performance Liquid Chromatography
التقدير الكمي لعقار الكانديزرتان سيلكستيل و الهيدروكلوروثايزيد باستخدام كروماتوجرافيا السائل ذي الأداء العالي
 
Subject : Original Articles 
Document Language : English 
Abstract : A high performance liquid chromatographic method was developed for simultaneous determination of candesartan cilexetil and hydrochlorothiazide in binary mixtures and in pharmaceutical dosage forms. Active substances were separated by gradient system in the mobile phase, consisting of acetonitrile and 0.02M sodium acetate. The flow rate of the mobile phase was 1 mL/min. Separation was achieved on Kromasil 100 C18 column (4.6 mm i.d. × x 25 cm length, 5 µm). Detection was carried out using UV detector set at 265 nm. The detector response was linear in the range of 16- – 200 ng/injection (10 µl) for candesartan cilexetil and 12.5- – 1250 ng/injection (10 µl) for hydrochlorothiazide. The relative standard deviation of the recovered amounts of candesartan and hydrochlorothiazide were 0.27 and 0.60%, respectively. The limit of detections were 4 ± 0.05 and 5 ± 0.06 ng/injection for hydrochlorothiazide and, candesartan, respectively. The method was  
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 15 
Issue Number : 2 
Publishing Year : 1429 AH
2008 AD 
Number Of Pages : 10 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
علاءالدين محمود خضرAlaa E. M. Khedr Researcher  

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