Document Details

Document Type : Article In Journal 
Document Title :
Synthesis of Certain New Dibenz[c,e]azepine-5,7-diones of Expected Antihyperlipidemic Activity
تصميم و تشييد بعض المركبات الجديدة من نواة داي بنز (سي , أي) أزيبين-5 و 7-دايون كمثبطات لمستوى دهون الدم
 
Subject : Original Articles 
Document Language : English 
Abstract : The structural requirements for decreasing cholesterol and triglyceride levels remain largely uninvestigated. Thus a systematic investigation of certain N-substituted dibenz[c,e]azepines is necessary. Twenty-four compounds of certain new N-substituted derivatives of dibenz[c,e]azepines-5,7-diones were synthesized and tested for their anticholestesrolemic and antitriglyceridimic activities. The evaluation of antihyperlipidemic activity of dibenz[c,e]azepine-5,7-diones (VII, X-XII) against Triton-WR1339-induced hyperlipidemia in rats showed a significant lowering of serum total cholesterol and triglyceride levels at a dose of 150 mg/kg compared with the control value. The phenyl substituted derivatives of diphenimide have shown a pronounced decrease in both triglyceride and cholesterol levels 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 14 
Issue Number : 4 
Publishing Year : 1428 AH
2007 AD 
Number Of Pages : 14 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
صابر السيد بركات Saber El-S. BarakatResearcher  
محمد أيمن عبدالهادي الذهبي Mohamed A. A. El-ZahabiResearcher  
أشرف عبدالعزيز عبدالرحمن Ashraf A. AbdelrahmanResearcher  
أشرف حسن بيومي Ashraf H. BayomiResearcher  
هاني عمري علي Hany E. AliResearcher  
منير عبدالسميع أمينMonir A. S. AminResearcher  

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