Document Details

Document Type : Article In Journal 
Document Title :
Correlation between Irradiated Small Bowel Volume and Toxicity in Rectal Cancer Patients Receiving Concomitant Pelvic Irradiation and 5-Fluorouracil Chemotherapy
العلاقة بين حجم الأمعاء الدقيقة المتعرضة للأشعة والآثار الجانبية في مرضى سرطان المستقيم المعالجين بالأشعة للحوض مع ( 5 ) الفلورو - يوراسيل الكيماوي
 
Subject : Original Articles 
Document Language : English 
Abstract : The aim is to study the relationship between radiation induced small bowel toxicity and radiation dose received by the small bowel during pelvic irradiation for patients with rectal cancer treated with pelvic radiotherapy and concomitant 5-Fluorouracil. Thirty-two patients with rectal cancer were referred for either a postoperative or preoperative pelvic irradiation concomitant with 5-Fluorouracil chemotherapy at the Radiotherapy Unit of King Abdulaziz University Hospital. All patients had computerized 3D treatment planning. Radiation therapy was given in two phases, to a total dose of 5040 cGy / 28 fractions / 5.5 weeks. Small bowel loops were contoured on CT cuts and a dose volume histogram was constructed and the mean radiation dose received by the small bowel, the volume of the small bowel irradiated and the mean radiation dose / volume of small bowel involved ratio. Univariate analysis showed a significant association between small bowel toxicity and mean radiation therapy dose received by small bowel (p = 0.001), the volume of small bowel involved (P = 0.043) and the type of surgical intervention with higher incidence for those patients who had abdominoperineal resection (P = 0.003). In conclusion, this study confirms the relation between small bowel toxicity and the volume of small bowel receiving radiotherapy. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 13 
Issue Number : 2 
Publishing Year : 1427 AH
2006 AD 
Number Of Pages : 9 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ياسر عبدالعزيز بهادرYasir A. BahadurResearcher  

Files

File NameTypeDescription
 22238.pdf pdf 

Back To Researches Page